Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow

Purine analogs such as 6-thioguanine (6TG) cause myelotoxicity upon conversion into nucleotides by hypoxanthine-guanine phosphoribosyltransferase (HPRT). Here we have developed a novel and highly efficient strategy employing 6TG as a single agent for both conditioning and in vivo chemoselection of H...

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Bibliografiset tiedot
Julkaisussa:Exp Hematol
Päätekijät: Hacke, Katrin, Szakmary, Akos, Cuddihy, Andrew R, Rozengurt, Nora, Lemp, Nathan A, Aubrecht, Jiri, Lawson, Gregory W, Rao, Nagesh P, Crooks, Gay M, Schiestl, Robert H., Kasahara, Noriyuki
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4305396/
https://ncbi.nlm.nih.gov/pubmed/22001673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2011.09.009
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