Two Novel α7 Nicotinic Acetylcholine Receptor Ligands: In Vitro Properties and Their Efficacy in Collagen-Induced Arthritis in Mice

INTRODUCTION: The cholinergic anti-inflammatory pathway can downregulate inflammation via the release of acetylcholine (ACh) by the vagus nerve. This neurotransmitter binds to the α7 subunit of nicotinic acetylcholine receptors (α7nAChR), expressed on macrophages and other immune cells. We tested th...

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Publicat a:PLoS One
Autors principals: van Maanen, Marjolein A., Papke, Roger L., Koopman, Frieda A., Koepke, Jessica, Bevaart, Lisette, Clark, Roger, Lamppu, Diana, Elbaum, Daniel, LaRosa, Gregory J., Tak, Paul P., Vervoordeldonk, Margriet J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4305287/
https://ncbi.nlm.nih.gov/pubmed/25617631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116227
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