Two Novel α7 Nicotinic Acetylcholine Receptor Ligands: In Vitro Properties and Their Efficacy in Collagen-Induced Arthritis in Mice

INTRODUCTION: The cholinergic anti-inflammatory pathway can downregulate inflammation via the release of acetylcholine (ACh) by the vagus nerve. This neurotransmitter binds to the α7 subunit of nicotinic acetylcholine receptors (α7nAChR), expressed on macrophages and other immune cells. We tested th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: van Maanen, Marjolein A., Papke, Roger L., Koopman, Frieda A., Koepke, Jessica, Bevaart, Lisette, Clark, Roger, Lamppu, Diana, Elbaum, Daniel, LaRosa, Gregory J., Tak, Paul P., Vervoordeldonk, Margriet J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4305287/
https://ncbi.nlm.nih.gov/pubmed/25617631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116227
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