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Engineering toxin-resistant therapeutic stem cells to treat brain tumors
Pseudomonas exotoxin (PE) potently blocks protein synthesis by catalyzing the inactivation of elongation factor-2 (EF-2), and PE-cytotoxins have been used as anti-tumor agents. However, their effective clinical translation in solid tumors has been confounded by off-target delivery, systemic toxicity...
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| Publicado no: | Stem Cells |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4305025/ https://ncbi.nlm.nih.gov/pubmed/25346520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1874 |
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