Human mesenchymal stromal cells attenuate graft-versus-host disease and maintain graft-versus-leukemia activity following experimental allogeneic bone marrow transplantation()

We sought to define the effects and underlying mechanisms of human, marrow-derived mesenchymal stromal cells (hMSCs) on graft-versus-host disease (GvHD) and graft-versus-leukemia (GvL) activity. Irradiated B6D2F1 mice given C57BL/6 BM and splenic T-cells and treated with hMSCs had reduced systemic G...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Auletta, Jeffery J., Eid, Saada K., Wuttisarnwattana, Patiwet, Silva, Ines, Metheny, Leland, Keller, Matthew D., Guardia-Wolff, Rocio, Liu, Chen, Wang, Fangjing, Bowen, Theodore, Lee, Zhenghong, Solchaga, Luis A., Ganguly, Sudipto, Tyler, Megan, Wilson, David L., Cooke, Kenneth R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304927/
https://ncbi.nlm.nih.gov/pubmed/25336340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1867
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