Antagonizing Bcl-2 Family Members Sensitizes Neuroblastoma and Ewing’s Sarcoma to an Inhibitor of Glutamine Metabolism

Neuroblastomas (NBL) and Ewing’s sarcomas (EWS) together cause 18% of all pediatric cancer deaths. Though there is growing interest in targeting the dysregulated metabolism of cancer as a therapeutic strategy, this approach has not been fully examined in NBL and EWS. In this study, we first tested a...

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Udgivet i:PLoS One
Main Authors: Olsen, Rachelle R., Mary-Sinclair, Michelle N., Yin, Zhirong, Freeman, Kevin W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304844/
https://ncbi.nlm.nih.gov/pubmed/25615615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116998
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