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Chromatin De-Compaction By The Nucleosomal Binding Protein HMGN5 Impairs Nuclear Sturdiness

In most metazoan nuclei, heterochromatin is located at the nuclear periphery in contact with the nuclear lamina, which provides mechanical stability to the nucleus. We show that in cultured cells, chromatin de-compaction by the nucleosome binding protein HMGN5 decreases the sturdiness, elasticity, a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Furusawa, Takashi, Rochman, Mark, Taher, Leila, Dimitriadis, Emilios K., Nagashima, Kunio, Anderson, Stasia, Bustin, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304400/
https://ncbi.nlm.nih.gov/pubmed/25609380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7138
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