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A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: Evidence for passive and facilitated transport

The gill is the principle site of xenobiotic transfer to and from the aqueous environment. To replace, refine or reduce (3Rs) the large numbers of fish used in in vivo uptake studies an effective in vitro screen is required that mimics the function of the teleost gill. This study uses a rainbow trou...

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Detalles Bibliográficos
Publicado en:Aquat Toxicol
Main Authors: Stott, Lucy C., Schnell, Sabine, Hogstrand, Christer, Owen, Stewart F., Bury, Nic R.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier/North Holland Biomedical Press 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303912/
https://ncbi.nlm.nih.gov/pubmed/25544062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.aquatox.2014.12.007
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