Reduced Lipoapoptosis, Hedgehog Pathway Activation, and Fibrosis in Caspase-2 deficient Mice with Nonalcoholic Steatohepatitis

OBJECTIVE: Caspase-2 is an initiator caspase involved in multiple apoptotic pathways, particularly in response to specific intracellular stressors (eg. DNA damage, ER stress). We recently reported that caspase-2 was pivotal for the induction of cell death triggered by excessive intracellular accumul...

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Pubblicato in:Gut
Autori principali: Machado, MV, Michelotti, GA, Pereira de Almeida, T, Boursier, J, Kruger, L, Swiderska-Syn, M, Karaca, G, Xie, G, Guy, CD, Bohnic, B, Lindblom, KR, Johnson, E, Kornbluth, S, Diehl, AM
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303564/
https://ncbi.nlm.nih.gov/pubmed/25053716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-307362
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