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Modulation of Calmodulin Lobes by Different Targets: An Allosteric Model with Hemiconcerted Conformational Transitions

Calmodulin is a calcium-binding protein ubiquitous in eukaryotic cells, involved in numerous calcium-regulated biological phenomena, such as synaptic plasticity, muscle contraction, cell cycle, and circadian rhythms. It exibits a characteristic dumbell shape, with two globular domains (N- and C-term...

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Foilsithe in:PLoS Comput Biol
Main Authors: Lai, Massimo, Brun, Denis, Edelstein, Stuart J., Le Novère, Nicolas
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303274/
https://ncbi.nlm.nih.gov/pubmed/25611683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004063
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