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The differential activation of intracellular signaling pathways confers the permissiveness of embryonic stem cell derivation from different mouse strains

The requirement of leukemia inhibitory factor (LIF) for the establishment and maintenance of mouse embryonic stem cells (ESCs) depends on the genetic background of the ESC origin. To reveal the molecular basis of the strain-dependent function of LIF, we compared the activation of the intracellular s...

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Detalles Bibliográficos
Publicado en:Development
Main Authors: Ohtsuka, Satoshi, Niwa, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists 2015
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302992/
https://ncbi.nlm.nih.gov/pubmed/25564647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.112375
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