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IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T cell-mediated colitis
Polymorphisms attenuating IL-10 signaling confer genetic risk for inflammatory bowel disease. Yet how IL-10 prevents mucosal autoinflammation is incompletely understood. We demonstrate using lineage-specific deletions of IL-10Rα that IL-10 acts primarily through macrophages to limit colitis. Colitis...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4302761/ https://ncbi.nlm.nih.gov/pubmed/25607885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7131 |
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