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SLAM: Cross-Species Gene Finding and Alignment with a Generalized Pair Hidden Markov Model

Comparative-based gene recognition is driven by the principle that conserved regions between related organisms are more likely than divergent regions to be coding. We describe a probabilistic framework for gene structure and alignment that can be used to simultaneously find both the gene structure a...

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Autors principals: Alexandersson, Marina, Cawley, Simon, Pachter, Lior
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2003
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC430255/
https://ncbi.nlm.nih.gov/pubmed/12618381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.424203
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