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Omalizumab Increases the Intrinsic Sensitivity of Human Basophils to IgE-Mediated Stimulation

BACKGROUND: Treatment of allergic patients with omalizumab results in a paradoxical increase in their basophil histamine release response, ex vivo, to crosslinking anti-IgE antibody. It is not known whether this change in response is associated with an increase in intrinsic cellular sensitivity, whi...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: MacGlashan, Donald, Saini, Sarbjit S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302343/
https://ncbi.nlm.nih.gov/pubmed/23791510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2013.04.056
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