Anthracycline-free neoadjuvant therapy induces pathological complete responses by exploiting immune proficiency in HER2+ breast cancer patients

BACKGROUND: Neoadjuvant Chemotherapy (NC) including trastuzumab induces a high rate of pathological Complete Responses (pCR) in patients with locally advanced HER2-overexpressing Breast Cancer (BC), but is penalized by a severe cardiotoxicity when combined with anthracyclines. A phase II study was d...

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Vydáno v:BMC Cancer
Hlavní autoři: Miolo, Gianmaria, Muraro, Elena, Martorelli, Debora, Lombardi, Davide, Scalone, Simona, Spazzapan, Simon, Massarut, Samuele, Perin, Tiziana, Viel, Elda, Comaro, Elisa, Talamini, Renato, Bidoli, Ettore, Turchet, Elisa, Crivellari, Diana, Dolcetti, Riccardo
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302069/
https://ncbi.nlm.nih.gov/pubmed/25512030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-954
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