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P301L Tau Expression Affects Glutamate Release and Clearance in the Hippocampal Trisynaptic Pathway

Individuals at risk of developing Alzheimer’s disease (AD) often exhibit hippocampal hyperexcitability. A growing body of evidence suggests perturbations in the glutamatergic tripartite synapse may underlie this hyperexcitability. Here, we used a tau mouse model of AD (rTg(TauP301L)4510) to examine...

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Detalhes bibliográficos
Publicado no:J Neurochem
Main Authors: Hunsberger, Holly C., Rudy, Carolyn C., Batten, Seth R., Gerhardt, Greg A., Reed, Miranda N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302046/
https://ncbi.nlm.nih.gov/pubmed/25319522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12967
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