Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells

BACKGROUND: Genome-wide saturation mutagenesis and subsequent phenotype-driven screening has been central to a comprehensive understanding of complex biological processes in classical model organisms such as flies, nematodes, and plants. The degree of “saturation” (i.e., the fraction of possible tar...

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Pubblicato in:BMC Genomics
Autori principali: Tokunaga, Masahiro, Kokubu, Chikara, Maeda, Yusuke, Sese, Jun, Horie, Kyoji, Sugimoto, Nakaba, Kinoshita, Taroh, Yusa, Kosuke, Takeda, Junji
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301880/
https://ncbi.nlm.nih.gov/pubmed/25418962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-1016
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