Elevated Levels of Somatic Mutation in a Manifesting BRCA1 Mutation Carrier

Homozygous loss of activity at the breast cancer-predisposing genes BRCA1 and BRCA2 (FANCD1) confers increased susceptibility to DNA double strand breaks, but this genotype occurs only in the tumor itself, following loss of heterozygosity at one of these loci. Thus, if these genes play a role in tum...

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Bibliografske podrobnosti
izdano v:Pathol Oncol Res
Main Authors: GRANT, Stephen G., DAS, Rubina, CERCEO, Christina M., RUBINSTEIN, Wendy S., LATIMER, Jean J.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301730/
https://ncbi.nlm.nih.gov/pubmed/18158561
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