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Expression of Interferon Gamma by a Recombinant Rabies Virus Strongly Attenuates the Pathogenicity of the Virus via Induction of Type I Interferon

Previous animal model experiments have shown a correlation between interferon gamma (IFN-γ) expression and both survival from infection with attenuated rabies virus (RABV) and reduction of neurological sequelae. Therefore, we hypothesized that rapid production of murine IFN-γ by the rabies virus its...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Barkhouse, Darryll A., Garcia, Samantha A., Bongiorno, Emily K., Lebrun, Aurore, Faber, Milosz, Hooper, D. Craig
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301114/
https://ncbi.nlm.nih.gov/pubmed/25320312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01572-14
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