Characterization of a Proteolytically Stable D-Peptide That Suppresses Herpes Simplex Virus 1 Infection: Implications for the Development of Entry-Based Antiviral Therapy

Uncontrolled herpes simplex virus 1 (HSV-1) infection can advance to serious conditions, including corneal blindness or fatal encephalitis. Here, we describe a highly potent anti-HSV-1 peptide (DG2) that inhibits HSV-1 entry into host cells and blocks all aspects of infection. Importantly, DG2 is hi...

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Bibliographic Details
Published in:J Virol
Main Authors: Jaishankar, Dinesh, Yakoub, Abraam M., Bogdanov, Anita, Valyi-Nagy, Tibor, Shukla, Deepak
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300769/
https://ncbi.nlm.nih.gov/pubmed/25428865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02979-14
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