Nuclear Import of Adenovirus DNA Involves Direct Interaction of Hexon with an N-Terminal Domain of the Nucleoporin Nup214

In this study, we characterized the molecular basis for binding of adenovirus (AdV) to the cytoplasmic face of the nuclear pore complex (NPC), a key step during delivery of the viral genome into the nucleus. We used RNA interference (RNAi) to deplete cells of either Nup214 or Nup358, the two major P...

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Bibliographic Details
Published in:J Virol
Main Authors: Cassany, Aurélia, Ragues, Jessica, Guan, Tinglu, Bégu, Dominique, Wodrich, Harald, Kann, Michael, Nemerow, Glen R., Gerace, Larry
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300731/
https://ncbi.nlm.nih.gov/pubmed/25410864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02639-14
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