Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines In Vitro and in Murine Hepatocytes In Vivo

We have previously reported that the removal of a 20-nucleotide sequence, termed the D sequence, from both ends of the inverted terminal repeats (ITRs) in the adeno-associated virus serotype 2 (AAV2) genome significantly impairs rescue, replication, and encapsidation of the viral genomes (X. S. Wang...

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Vydáno v:J Virol
Hlavní autoři: Ling, Chen, Wang, Yuan, Lu, Yuan, Wang, Lina, Jayandharan, Giridhara R., Aslanidi, George V., Li, Baozheng, Cheng, Binbin, Ma, Wenqin, Lentz, Thomas, Ling, Changquan, Xiao, Xiao, Samulski, R. Jude, Muzyczka, Nicholas, Srivastava, Arun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Gene Delivery
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300666/
https://ncbi.nlm.nih.gov/pubmed/25355884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02581-14
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