Low levels of tissue factor pathway inhibitor increase the risk of cerebral venous thrombosis

BACKGROUND: Decreased concentration of tissue factor pathway inhibitor (TFPI) is a risk factor for development of deep venous thrombosis and coronary heart disease, but there is no evidence for the relationship between TFPI and cerebral venous and sinus thrombosis (CVST). The aim of this study was t...

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Publicado no:Adv Biomed Res
Main Authors: Javanmard, Shaghayegh Haghjooy, Shahsavarzadeh, Tayebeh, Saadatnia, Mohammad
Formato: Artigo
Idioma:Inglês
Publicado em: Medknow Publications & Media Pvt Ltd 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300595/
https://ncbi.nlm.nih.gov/pubmed/25625112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/2277-9175.148287
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spelling pubmed-43005952015-01-26 Low levels of tissue factor pathway inhibitor increase the risk of cerebral venous thrombosis Javanmard, Shaghayegh Haghjooy Shahsavarzadeh, Tayebeh Saadatnia, Mohammad Adv Biomed Res Original Article BACKGROUND: Decreased concentration of tissue factor pathway inhibitor (TFPI) is a risk factor for development of deep venous thrombosis and coronary heart disease, but there is no evidence for the relationship between TFPI and cerebral venous and sinus thrombosis (CVST). The aim of this study was to determine the level of TFPI in healthy population and in patients with CVST. MATERIALS AND METHODS: We determined the plasma level of TFPI in 20 patients with CVST (cases) and 31 healthy volunteer subjects (as control group) by enzyme linked immunoassay method. We also examined the association between TFPI and the risk of CVST. Continuous variables were compared between groups using Student's t test, and odds ratio was calculated by multiple logistic regression analysis. RESULTS: The mean TFPI was significantly lower in the CVST group compared with the control group (8.60 ± 4.05 ng/mL; 14.6 ± 8.6 ng/mL; P = 0. 005), respectively. The odds ratio for CVST associated with low (<25(th) percentile) levels of TFPI was 5.429 (95% CI, 1.487-19.82, P = 0.012). CONCLUSION: Our investigation demonstrates that reduced TFPI may be one of the risk factors of CVST and associated with increasing the risk of developing CVST. Medknow Publications & Media Pvt Ltd 2015-01-06 /pmc/articles/PMC4300595/ /pubmed/25625112 http://dx.doi.org/10.4103/2277-9175.148287 Text en Copyright: © 2015 Javanmard http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Original Article
spellingShingle Original Article
Javanmard, Shaghayegh Haghjooy
Shahsavarzadeh, Tayebeh
Saadatnia, Mohammad
Low levels of tissue factor pathway inhibitor increase the risk of cerebral venous thrombosis
description BACKGROUND: Decreased concentration of tissue factor pathway inhibitor (TFPI) is a risk factor for development of deep venous thrombosis and coronary heart disease, but there is no evidence for the relationship between TFPI and cerebral venous and sinus thrombosis (CVST). The aim of this study was to determine the level of TFPI in healthy population and in patients with CVST. MATERIALS AND METHODS: We determined the plasma level of TFPI in 20 patients with CVST (cases) and 31 healthy volunteer subjects (as control group) by enzyme linked immunoassay method. We also examined the association between TFPI and the risk of CVST. Continuous variables were compared between groups using Student's t test, and odds ratio was calculated by multiple logistic regression analysis. RESULTS: The mean TFPI was significantly lower in the CVST group compared with the control group (8.60 ± 4.05 ng/mL; 14.6 ± 8.6 ng/mL; P = 0. 005), respectively. The odds ratio for CVST associated with low (<25(th) percentile) levels of TFPI was 5.429 (95% CI, 1.487-19.82, P = 0.012). CONCLUSION: Our investigation demonstrates that reduced TFPI may be one of the risk factors of CVST and associated with increasing the risk of developing CVST.
author Javanmard, Shaghayegh Haghjooy
Shahsavarzadeh, Tayebeh
Saadatnia, Mohammad
author_facet Javanmard, Shaghayegh Haghjooy
Shahsavarzadeh, Tayebeh
Saadatnia, Mohammad
author_sort Javanmard, Shaghayegh Haghjooy
title Low levels of tissue factor pathway inhibitor increase the risk of cerebral venous thrombosis
title_short Low levels of tissue factor pathway inhibitor increase the risk of cerebral venous thrombosis
title_full Low levels of tissue factor pathway inhibitor increase the risk of cerebral venous thrombosis
title_fullStr Low levels of tissue factor pathway inhibitor increase the risk of cerebral venous thrombosis
title_full_unstemmed Low levels of tissue factor pathway inhibitor increase the risk of cerebral venous thrombosis
title_sort low levels of tissue factor pathway inhibitor increase the risk of cerebral venous thrombosis
publisher Medknow Publications & Media Pvt Ltd
container_title Adv Biomed Res
publishDate 2015
url https://ncbi.nlm.nih.gov/pmc/articles/PMC4300595/
https://ncbi.nlm.nih.gov/pubmed/25625112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/2277-9175.148287
_version_ 1803272987310292992

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