ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma

Treatment of BRAF mutant melanomas with specific BRAF inhibitors leads to tumor remission. However, most patients eventually relapse due to drug resistance. Therefore, we designed an integrated strategy using (phospho)proteomic and functional genomic platforms to identify drug targets whose inhibiti...

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Detalhes bibliográficos
Publicado no:Mol Syst Biol
Main Authors: Smit, Marjon A, Maddalo, Gianluca, Greig, Kylie, Raaijmakers, Linsey M, Possik, Patricia A, van Breukelen, Bas, Cappadona, Salvatore, Heck, Albert JR, Altelaar, AF Maarten, Peeper, Daniel S
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300494/
https://ncbi.nlm.nih.gov/pubmed/25538140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20145450
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