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Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid
PURPOSE: To develop predictive models of apparent solubility (S(app)) of lipophilic drugs in fasted state simulated intestinal fluid (FaSSIF) and aspirated human intestinal fluid (HIF). METHODS: Measured S(app) values in FaSSIF, HIF and phosphate buffer pH 6.5 (PhB(pH6.5)) for 86 lipophilic drugs we...
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| Publicado no: | Pharm Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4300419/ https://ncbi.nlm.nih.gov/pubmed/25186438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-014-1487-z |
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