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Autocrine Boost of NMDAR Current in Hippocampal CA1 Pyramidal Neurons by a PMCA-Dependent, Perisynaptic, Extracellular pH Shift
The plasma membrane Ca(2+)-ATPase (PMCA) is found near postsynaptic NMDARs. This transporter is a Ca(2+)-H(+) exchanger that raises cell surface pH. We tested whether the PMCA acts in an autocrine fashion to boost pH-sensitive, postsynaptic NMDAR currents. In mouse hippocampal slices, NMDAR EPSCs in...
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| Publicado no: | J Neurosci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4300330/ https://ncbi.nlm.nih.gov/pubmed/25609607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2293-14.2015 |
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