17β-estradiol suppresses lipopolysaccharide-induced acute lung injury through PI3K/Akt/SGK1 mediated up-regulation of epithelial sodium channel (ENaC) in vivo and in vitro

BACKGROUND: 17β-estradiol can suppress acute lung injury (ALI) and regulate alveolar epithelial sodium channel (ENaC). However the relationship between these two functions remains unclear. This study is conducted to assess the role of ENaC and the PI3K/Akt/SGK1 signaling pathway in 17β-estradiol the...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Qi, Di, He, Jing, Wang, Daoxin, Deng, Wang, Zhao, Yan, Ye, Yuan, Feng, Longhua
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299800/
https://ncbi.nlm.nih.gov/pubmed/25551628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-014-0159-1
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