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Measuring error rates in genomic perturbation screens: gold standards for human functional genomics
Technological advancement has opened the door to systematic genetics in mammalian cells. Genome-scale loss-of-function screens can assay fitness defects induced by partial gene knockdown, using RNA interference, or complete gene knockout, using new CRISPR techniques. These screens can reveal the bas...
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| Опубликовано в: : | Mol Syst Biol |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Blackwell Publishing Ltd
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4299491/ https://ncbi.nlm.nih.gov/pubmed/24987113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20145216 |
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