Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

Technological advancement has opened the door to systematic genetics in mammalian cells. Genome-scale loss-of-function screens can assay fitness defects induced by partial gene knockdown, using RNA interference, or complete gene knockout, using new CRISPR techniques. These screens can reveal the bas...

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Bibliographic Details
Published in:Mol Syst Biol
Main Authors: Hart, Traver, Brown, Kevin R, Sircoulomb, Fabrice, Rottapel, Robert, Moffat, Jason
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299491/
https://ncbi.nlm.nih.gov/pubmed/24987113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20145216
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