Mutations in POLE and survival of colorectal cancer patients – link to disease stage and treatment

Recent molecular profiling studies reported a new class of ultramutated colorectal cancers (CRCs), which are caused by exonuclease domain mutations (EDMs) in DNA polymerase ε (POLE). Data on the clinical implications of these findings as to whether these mutations define a unique CRC entity with dis...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Stenzinger, Albrecht, Pfarr, Nicole, Endris, Volker, Penzel, Roland, Jansen, Lina, Wolf, Thomas, Herpel, Esther, Warth, Arne, Klauschen, Frederick, Kloor, Matthias, Roth, Wilfried, Bläker, Hendrik, Chang-Claude, Jenny, Brenner, Hermann, Hoffmeister, Michael, Weichert, Wilko
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Clinical Cancer Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298379/
https://ncbi.nlm.nih.gov/pubmed/25124163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.305
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