Low-dose dexamethasone as a treatment for women with heavy menstrual bleeding: protocol for response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)

INTRODUCTION: Heavy menstrual bleeding (HMB) diminishes individual quality-of-life and poses substantial societal burden. In HMB endometrium, inactivation of cortisol (by enzyme 11β hydroxysteroid dehydrogenase type 2 (11βHSD2)), may cause local endometrial glucocorticoid deficiency and hence increa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:BMJ Open
Prif Awduron: Warner, P, Weir, C J, Hansen, C H, Douglas, A, Madhra, M, Hillier, S G, Saunders, P T K, Iredale, J P, Semple, S, Walker, B R, Critchley, H O D
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMJ Publishing Group 2015
Pynciau:
Obstetrics and Gynaecology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298087/
https://ncbi.nlm.nih.gov/pubmed/25588784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2014-006837
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