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The functional polymorphism rs73598374:G>A (p.Asp8Asn) of the ADA gene is associated with telomerase activity and leukocyte telomere length

Recent evidence demonstrated a relevant role of adenosine deaminase (ADA) in replicative senescence of T cells through its capacity to modulate telomerase activity (TA). Herein, we tested the impact of the functional polymorphism ADA rs73598374:G>A (c.22G>A, p.Asp8Asn) on telomere biology, by...

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Detalhes bibliográficos
Publicado no:Eur J Hum Genet
Main Authors: Concetti, Fabio, Carpi, Francesco M, Nabissi, Massimo, Picciolini, Matteo, Santoni, Giorgio, Napolioni, Valerio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297891/
https://ncbi.nlm.nih.gov/pubmed/24896148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2014.102
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