Pyramidal cell selective ablation of NMDA-R1 causes increase in cellular and network excitability

BACKGROUND: Neuronal activity at gamma frequency is impaired in schizophrenia (SZ) and is considered critical for cognitive performance. Such impairments are thought to be due to reduced N-Methyl-D-Aspartate Receptor (NMDAR)-mediated inhibition from parvalbumin (PV) interneurons, rather than a direc...

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Publicado no:Biol Psychiatry
Main Authors: Tatard-Leitman, Valerie M., Jutzeler, Catherine R., Suh, Jimmy, Saunders, John A., Billingslea, Eddie N., Morita, Susumu, White, Rachel, Featherstone, Robert E., Ray, Rabindranath, Ortinski, Pavel I., Banerjee, Anamika, Gandal, Michael J., Lin, Robert, Alexandrescu, Anamaria, Liang, Yuling, Gur, Raquel E., Borgmann-Winter, Karin E., Carlson, Gregory C., Hahn, Chang-Gyu, Siegel, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297754/
https://ncbi.nlm.nih.gov/pubmed/25156700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2014.06.026
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