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Orientation of Myosin Binding Protein C in the Cardiac Muscle Sarcomere Determined by Domain-Specific Immuno-EM

Myosin binding protein-C is a thick filament protein of vertebrate striated muscle. The cardiac isoform (cMyBP-C) is essential for normal cardiac function, and mutations in cMyBP-C cause cardiac muscle disease. The rod-shaped molecule is composed primarily of 11 immunoglobulin- or fibronectin-like d...

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Veröffentlicht in:J Mol Biol
Hauptverfasser: Lee, Kyounghwan, Harris, Samantha P., Sadayappan, Sakthivel, Craig, Roger
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297556/
https://ncbi.nlm.nih.gov/pubmed/25451032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.10.023
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