Specific Action of 4-Nitropyridine 1-Oxide on Escherichia coli K-12 Pro(+) Strains Leading to the Isolation of Proline-Requiring Mutants: Isolation and Characterization of Pro(−) Mutants

A specific action of 4-nitropyridine 1-oxide on Escherichia coli K-12 Pro(+) strains leading to highly efficient, selective isolation of Pro(−) mutants is described. Incubation of Pro(+) cells with a sublethal concentration of 4-nitropyridine 1-oxide in Penassay broth gave Pro(−) mutants, which lack...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Inuzuka, Manabu, Miyano, Hiroshi, Tomoeda, Munemitsu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1976
Assuntos:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC429743/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/791096/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.10.2.325
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