Enzymatic Modification of Aminoglycoside Antibiotics: a New 6′-N-Acetylating Enzyme from a Pseudomonas aeruginosa Isolate

We describe an aminoglycoside 6′-N-acetyltransferase, isolated from Pseudomonas aeruginosa, that exhibits a novel substrate profile characterized by markedly reduced activity towards butirosin and amikacin.

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Bibliografische Detailangaben
Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Haas, M., Biddlecome, S., Davies, J., Luce, C. E., Daniels, P. J. L.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1976
Schlagworte:	Chemistry; Mechanisms of Action and Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC429655/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/820249/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.9.6.945
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Enzymatic Modification of Aminoglycoside Antibiotics: a New 6′-N-Acetylating Enzyme from a Pseudomonas aeruginosa Isolate

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