Germline Mutations in Shelterin Complex Genes Are Associated With Familial Glioma

Gliomas are the most common brain tumor, with several histological subtypes of various malignancy grade. The genetic contribution to familial glioma is not well understood. Using whole exome sequencing of 90 individuals from 55 families, we identified two families with mutations in POT1 (p.G95C, p.E...

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Publicat a:J Natl Cancer Inst
Autors principals: Bainbridge, Matthew N., Armstrong, Georgina N., Gramatges, M. Monica, Bertuch, Alison A., Jhangiani, Shalini N., Doddapaneni, Harsha, Lewis, Lora, Tombrello, Joseph, Tsavachidis, Spyros, Liu, Yanhong, Jalali, Ali, Plon, Sharon E., Lau, Ching C., Parsons, Donald W., Claus, Elizabeth B., Barnholtz-Sloan, Jill, Il’yasova, Dora, Schildkraut, Joellen, Ali-Osman, Francis, Sadetzki, Siegal, Johansen, Christoffer, Houlston, Richard S., Jenkins, Robert B., Lachance, Daniel, Olson, Sara H., Bernstein, Jonine L., Merrell, Ryan T., Wrensch, Margaret R., Walsh, Kyle M., Davis, Faith G., Lai, Rose, Shete, Sanjay, Aldape, Kenneth, Amos, Christopher I., Thompson, Patricia A., Muzny, Donna M., Gibbs, Richard A., Melin, Beatrice S., Bondy, Melissa L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Brief Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296199/
https://ncbi.nlm.nih.gov/pubmed/25482530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/dju384
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