Altered Ca(2+) Kinetics Associated with α-Actinin-3 Deficiency May Explain Positive Selection for ACTN3 Null Allele in Human Evolution

Over 1.5 billion people lack the skeletal muscle fast-twitch fibre protein α-actinin-3 due to homozygosity for a common null polymorphism (R577X) in the ACTN3 gene. α-Actinin-3 deficiency is detrimental to sprint performance in elite athletes and beneficial to endurance activities. In the human geno...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Head, Stewart I., Chan, Stephen, Houweling, Peter J., Quinlan, Kate G. R., Murphy, Robyn, Wagner, Sören, Friedrich, Oliver, North, Kathryn N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295894/
https://ncbi.nlm.nih.gov/pubmed/25590636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004862
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados