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Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids()
Using the amber suppression approach, four noncanonical amino acids (ncAAs) were used to replace existing amino acids at four positions in lasso peptide microcin J25 (MccJ25). The lasso peptide biosynthesis enzymes tolerated all four ncAAs and produced antibiotics with efficacy equivalent to wild-ty...
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| Published in: | Chem Commun (Camb) |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4295776/ https://ncbi.nlm.nih.gov/pubmed/25407838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc07778d |
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