Interplay Between HGF/SF–Met-Ras Signaling, Tumor Metabolism and Blood Flow as a Potential Target for Breast Cancer Therapy

High glucose uptake and increase blood flow is a characteristic of most metastatic tumors. Activation of Ras signaling increases glycolytic flux into lactate, de novo nucleic acid synthesis and uncoupling of ATP synthase from the proton gradient. Met tyrosine kinase receptor signaling upon activatio...

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Udgivet i:Oncoscience
Main Authors: Natan, Sari, Tsarfaty, Galia, Horev, Judith, Haklai, Roni, Kloog, Yoel, Tsarfaty, Ilan
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2013
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295761/
https://ncbi.nlm.nih.gov/pubmed/25593982
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