Unraveling the chromosome 17 patterns of FISH in interphase nuclei: an in-depth analysis of the HER2 amplicon and chromosome 17 centromere by karyotyping, FISH and M-FISH in breast cancer cells

BACKGROUND: In diagnostic pathology, HER2 status is determined in interphase nuclei by fluorescence in situ hybridization (FISH) with probes for the HER2 gene and for the chromosome 17 centromere (CEP17). The latter probe is used as a surrogate for chromosome 17 copies, however chromosome 17 (Chr17)...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Rondón-Lagos, Milena, Verdun Di Cantogno, Ludovica, Rangel, Nelson, Mele, Teresa, Ramírez-Clavijo, Sandra R, Scagliotti, Giorgio, Marchiò, Caterina, Sapino, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295336/
https://ncbi.nlm.nih.gov/pubmed/25481507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-922
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