Phase 1 trial of tivantinib in combination with sorafenib in adult patients with advanced solid tumors

Purpose This phase I study evaluated the safety, tolerability, maximum tolerated dose (MTD), and recommended phase II dose (RP2D) of tivantinib combined with sorafenib in patients with advanced solid tumors. Materials and Methods A standard 3 + 3 dose escalation design was used. At the RP2D, expansi...

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Detalles Bibliográficos
Publicado en:Invest New Drugs
Main Authors: Puzanov, Igor, Sosman, Jeffrey, Santoro, Armando, Saif, Muhammad W., Goff, Laura, Dy, Grace K., Zucali, Paolo, Means-Powell, Julie A., Ma, Wen Wee, Simonelli, Matteo, Martell, Robert, Chai, Feng, Lamar, Maria, Savage, Ronald E., Schwartz, Brian, Adjei, Alex A.
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2014
Assuntos:
Phase I Studies
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295023/
https://ncbi.nlm.nih.gov/pubmed/25294187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-014-0167-5
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