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Demethylating Drugs as Novel Analgesics for Cancer Pain

PURPOSE: In this study we evaluated the analgesic potential of demethylating drugs on oral cancer pain. While demethylating drugs could affect expression many genes, we focused on the mu-opioid receptor (OPRM1) gene pathway, because of its role in pain processing. We determined the antinociceptive e...

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Publicat a:Clin Cancer Res
Autors principals: Viet, Chi T., Dang, Dongmin, Ye, Yi, Ono, Kentaro, Campbell, Ronald R., Schmidt, Brian L.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294581/
https://ncbi.nlm.nih.gov/pubmed/24963050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0901
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