Relation Between Lipophilicity and Pharmacological Behavior of Minocycline, Doxycycline, Tetracycline, and Oxytetracycline in Dogs

Four tetracyclines were studied in dogs to determine the relation between their lipophilicity and various other pharmacological characteristics. Lipid solubility correlated inversely with the mean concentration of drug in arterial plasma and renal uptake and excretion, and directly with the biliary...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Barza, Michael, Brown, Richard B., Shanks, Carolyn, Gamble, Charles, Weinstein, Louis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1975
Assuntos:	Pharmacology and Therapeutics
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC429453/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1211925/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.8.6.713
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