STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters

Retinoblastoma, the most common intraocular malignant tumor in children, is characterized by the loss of both functional alleles of RB1 gene, which however alone cannot maintain malignant characteristics of retinoblastoma cells. Nevertheless, the investigation of other molecular aberrations such as...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Jo, Dong Hyun, Kim, Jin Hyoung, Cho, Chang Sik, Cho, Young-Lai, Jun, Hyoung Oh, Yu, Young Suk, Min, Jeong-Ki, Kim, Jeong Hun
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294389/
https://ncbi.nlm.nih.gov/pubmed/25359779
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