Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma

Metformin has been shown to inhibit tumor growth in xenograft rodent models of adult cancers, and various human clinical trials are in progress. However, the precise molecular mechanisms of metformin action are largely unknown. In the present study we examined the anti-tumor activity of metformin ag...

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Vydáno v:Oncotarget
Hlavní autoři: Kumar, Ambrish, Al-Sammarraie, Nadia, DiPette, Donald J., Singh, Ugra S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294363/
https://ncbi.nlm.nih.gov/pubmed/25365944
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