Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition

Docetaxel (DTX) is a useful chemotherapeutic drug for the treatment of hormone-refractory prostate cancer. However, emergence of DTX resistance has been a therapeutic hurdle. In this study, we investigated the effect of combining DTX with Bcl-2 family inhibitors using human prostate cancer cell line...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Tamaki, Hiroki, Harashima, Nanae, Hiraki, Miho, Arichi, Naoko, Nishimura, Nobuhiro, Shiina, Hiroaki, Naora, Kohji, Harada, Mamoru
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294332/
https://ncbi.nlm.nih.gov/pubmed/25333266
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