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Granzyme-Mediated Regulation of Host Defense in the Liver in Experimental Leishmania donovani Infection
In the livers of susceptible C57BL/6 (B6) mice infected with Leishmania donovani, CD8(+) T cell mechanisms are required for granuloma assembly, macrophage activation, intracellular parasite killing, and self-cure. Since gene expression of perforin and granzymes A and B (GzmA and GzmB), cytolytic pro...
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| Publié dans: | Infect Immun |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4294235/ https://ncbi.nlm.nih.gov/pubmed/25452549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02418-14 |
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