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Granzyme-Mediated Regulation of Host Defense in the Liver in Experimental Leishmania donovani Infection

In the livers of susceptible C57BL/6 (B6) mice infected with Leishmania donovani, CD8(+) T cell mechanisms are required for granuloma assembly, macrophage activation, intracellular parasite killing, and self-cure. Since gene expression of perforin and granzymes A and B (GzmA and GzmB), cytolytic pro...

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Bibliografski detalji
Izdano u:Infect Immun
Glavni autori: Murray, Henry W., Mitchell-Flack, Marisa, Zheng, Hua, Ma, Xiaojing
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294235/
https://ncbi.nlm.nih.gov/pubmed/25452549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02418-14
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