Recombinant Protein Truncation Strategy for Inducing Bactericidal Antibodies to the Macrophage Infectivity Potentiator Protein of Neisseria meningitidis and Circumventing Potential Cross-Reactivity with Human FK506-Binding Proteins

A recombinant macrophage infectivity potentiator (rMIP) protein of Neisseria meningitidis induces significant serum bactericidal antibody production in mice and is a candidate meningococcal vaccine antigen. However, bioinformatics analysis of MIP showed some amino acid sequence similarity to human F...

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Détails bibliographiques
Publié dans:Infect Immun
Auteurs principaux: Bielecka, Magdalena K., Devos, Nathalie, Gilbert, Mélanie, Hung, Miao-Chiu, Weynants, Vincent, Heckels, John E., Christodoulides, Myron
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Microbial Immunity and Vaccines
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294229/
https://ncbi.nlm.nih.gov/pubmed/25452551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01815-14
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