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Investigation of connexin 43 uncoupling and prolongation of the cardiac QRS complex in preclinical and marketed drugs

BACKGROUND AND PURPOSE: Prolongation of the cardiac QRS complex is linked to increased mortality and may result from drug-induced inhibition of cardiac sodium channels (hNa(V)1.5). There has been no systematic evaluation of preclinical and marketed drugs for their additional potential to cause QRS p...

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Bibliografski detalji
Izdano u:Br J Pharmacol
Glavni autori: Burnham, M P, Sharpe, P M, Garner, C, Hughes, R, Pollard, C E, Bowes, J
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294106/
https://ncbi.nlm.nih.gov/pubmed/24328991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12554
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