In vivo properties of KNT-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice

BACKGROUND AND PURPOSE: Activation of δ opioid (DOP) receptors regulates pain and emotional responses, and also displays ligand-biased agonism. KNT-127 (1,2,3,4,4a,5,12,12a-octahydro-2-methyl-4aβ,1β-([1,2]benzenomethano)-2,6-diazanaphthacene-12aβ,17-diol) is a novel DOP receptor agonist inducing ana...

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Dades bibliogràfiques
Publicat a:Br J Pharmacol
Autors principals: Nozaki, C, Nagase, H, Nemoto, T, Matifas, A, Kieffer, B L, Gaveriaux-Ruff, C
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294046/
https://ncbi.nlm.nih.gov/pubmed/25048778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12852
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